Changes in Shunt Flow, Compliance, and Volume of Lungs during Apneic Oxygenation.
نویسنده
چکیده
ANTHONISEN, NICHOLAS R. Changes in shunt JEozv, compliance, and volume of lungs during upneic oxygenation. Am. J. Physiol. 207 ( > I : 239-24 I. I g6+-Open-chested denitrogenated cats were studied during so-min periods of apneic oxygenation. Two lung volumes were selected, one about 25y0 of total lung capacity (TLC), and the other one about 55y0 of TLC. Serial measurements were made during apnea of pulmonary shunt flow (Q&t) and static pulmonary compliance (CL). Lung volumes were measured at the beginning and end of the period of apnea. Apneic oxygenation at .25 Y0 TLC regularly was associated with increasing Qs/(it, decreasing CL, and loss of lung volume signifying atelectasis. None of these phenomena were observed at 55% TLC. These results are discussed as they relate to time-dependent changes in the surface characteristics of the alveolar lining.
منابع مشابه
Respiratory compliance but not gas exchange correlates with changes in lung aeration after a recruitment maneuver: an experimental study in pigs with saline lavage lung injury
INTRODUCTION Atelectasis is a common finding in acute lung injury, leading to increased shunt and hypoxemia. Current treatment strategies aim to recruit alveoli for gas exchange. Improvement in oxygenation is commonly used to detect recruitment, although the assumption that gas exchange parameters adequately represent the mechanical process of alveolar opening has not been proven so far. The ai...
متن کاملEvaluation of Two Microporous Polypropylene Membrane Lungs for Extracorporeal Carbon Dioxide Removal during Apneic Oxygenation
_____________ _ Five Capiox II 33 (Terumo Corporation) and nine M-2000 (Shiley Incorporated) microporous polypropylene membrane lungs were evaluated for dynamic operating characteristics during apneic oxygenation. Particular emphasis was placed on carbon dioxide and oxygen transfer (VC02 and V02 respectively). The lungs were incorporated into extracorporeal venavenous bypass circuits used with ...
متن کاملProtective strategies for one-lung ventilation
provided the original work is properly cited. CC Hypoxemia and acute lung injury (ALI) are major concerns with one-lung ventilation (OLV) during thoracic surgery. Hypoxemia is usually the result of alveolar hypoventilation and an increasing shunt fraction, whereas ALI is caused by ventilatory stress (volutrauma, atelectrauma, and barotrauma), reexpansion pulmonary injury, and the lung surgery i...
متن کاملEffects of acute hemorrhage on intrapulmonary shunt in a pig model of acute respiratory distress-like syndrome.
BACKGROUND In acute respiratory distress syndrome (ARDS), gas exchange and respiratory system mechanics (compliance) are severely impaired. Besides ventilatory parameters, the degree of respiratory abnormality can be influenced by the circulatory state. This study investigated the influence of acute hypovolemia on the respiratory system. METHODS We performed a secondary analysis of a previous...
متن کاملBiologically variable ventilation improves oxygenation and respiratory mechanics during one-lung ventilation.
BACKGROUND Hypoxemia is common during one-lung ventilation (OLV). Atelectasis contributes to the problem. Biologically variable ventilation (BVV), using microprocessors to reinstitute physiologic variability to respiratory rate and tidal volume, has been shown to be advantageous over conventional monotonous control mode ventilation (CMV) in improving oxygenation during the period of lung reinfl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The American journal of physiology
دوره 207 شماره
صفحات -
تاریخ انتشار 1964